传染性肝炎病毒的鸡胚感染试验,最早在1941年由Siede、Meding氏开始,后来即由氏继续完成。氏等用九日令的鸡胚,接种多份传染性肝炎患者的血、便或胆汁,发现鸡胚可以在3-5日内死亡,有较高的阳性率。不少鸡胚中可以见到肉眼及显微镜下的病理改改,尤其是在肝脏。有病理改变的鸡胚材料(如浆尿膜研磨液)还可以在鸡胚传代,也能致其死亡。 The chicken embryo infection test of the infectious hepatitis virus was first started in 1941 by the Siede and the Meding, and was later completed by Shih. Shi et al. used nine-day-old chicken embryos to inoculate blood, stool, or bile in patients with multiple infectious hepatitis and found that chicken embryos could die within 3-5 days with a high positive rate. Many chicken embryos can be seen in the naked eye and under the microscope pathological changes, especially in the liver. Pathologically modified chick embryo materials (such as slurry) can also be passed to chicken embryos and can also cause death.