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内皮素(ET)是新近发现的一种活性多肽,具有强烈、持续的缩血管作用,对心血管、泌尿、生殖等系统都有重要影响,并且可与体内其它激素如心钠素(ANP)等相互作用,共同参与机体各种平衡的调节。但ET在肝硬变时的病理生理意义尚不清楚。我们测定了34例肝硬变患者血浆ET浓度,并就其与ANP的关系进行了初步探讨。1 对象和方法 34例肝硬变患者均为肝炎后肝硬变,男29例,女5例,平均年龄48.9岁。23例并发腹水,其中8例经治疗后腹水消退。正常人11例,男8例,
Endothelin (ET) is a recently discovered active polypeptide with a strong and sustained vasoconstrictor effect, which has an important effect on cardiovascular, urinary and reproductive systems and can interact with other hormones such as atrial natriuretic peptide (ANP) And other interactions, to participate in a variety of body balance adjustment. However, the pathophysiology of ET in cirrhosis is not clear. We measured plasma ET levels in 34 patients with cirrhosis and explored their relationship with ANP. 1 objects and methods 34 cases of cirrhosis patients with posthepatitic cirrhosis, 29 males and 5 females, mean age 48.9 years old. 23 cases of ascites, of which 8 cases of ascites subsided after treatment. 11 cases of normal, 8 males,