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:[目的]探讨端粒酶在乳腺癌中的活性表达情况。[方法]利用非放射性的PCR ELISA反应试剂盒检测51例乳腺癌及其中20例癌旁组织和9例正常乳腺组织的端粒酶活性。[结果]51例乳腺癌、20例癌旁组织和9例正常乳腺组织的端粒酶活性阳性率分别为82 4 %(42/51)、5 %(1/20)和0(0/9) ;乳腺癌中不同组织分类之间及不同临床分期之间的端粒酶活性阳性率均无显著差异(P>0 05)。[结论]端粒酶在绝大多数乳腺癌中表达 ,其活性与乳腺癌的组织分类、临床分期和肿瘤大小无相关性。
: [Objective] To investigate the expression of telomerase activity in breast cancer. [Methods] The non-radioactive PCR ELISA kit was used to detect the telomerase activity in 51 cases of breast cancer, 20 cases of adjacent tissues and 9 cases of normal breast tissues. [Results] The positive rates of telomerase activity in 51 cases of breast cancer, 20 cases of adjacent tissues and 9 cases of normal breast tissues were 82.4% (42/51), 5% (1/20) and 0 (0/9), respectively. There was no significant difference in the positive rate of telomerase activity between different tissue classifications and clinical stages in breast cancer (P>0.05). [Conclusion] Telomerase is expressed in most breast cancers, and its activity is not related to the tissue classification, clinical stage, and tumor size of breast cancer.