目的应用体表胃电图研究尿毒症患者是否存在胃肌电活动损害．方法应用双电极ＤｉｇｇｔｒａｐｐｅｒＥＧＧ对２５例有胃肠道症状的尿毒症患者和２５例健康志愿者进行餐前、餐后各３０ｍｉｎ胃电图检查，试餐２００８３２ＫＪ（１００ｇ营养麦片，２００ｍＬ开水）．结果健康组餐前主频（ＤＦ）、主功率（ＤＰ）及正常节律百分比（Ｎ％）分别为２９ｍｉｎ－１±０１ｍｉｎ－１，５７６ｂｐ±１５２ｂｐ，９０９％±１９％；餐后：３０ｍｉｎ－１±０１ｍｉｎ－１，２１２７８ｂｐ±７２５ｂｐ（Ｐ＜００１），９２６％±２１％．尿毒症组餐前ＤＦ、ＤＰ、Ｎ％分别为１１ｍｉｎ－１±０２ｍｉｎ－１，６５０４ｂｐ±４８０ｂｐ，４７０％±３９％；餐后１２ｍｉｎ－１±０２ｍｉｎ－１，３６４８ｂｐ±２４５ｂｐ，３３８％±３１％．以上结果与健康组相比均有显著性差异．结论尿毒症患者存在胃电节律紊乱，此种节律紊乱主要表现在正常节律百分比明显下降及餐后功率降低，提示尿毒症患者存在胃肌电活动异常．ＥＧＧ作为一种无创性胃动力检查方法，可用于严重肾功能衰竭、尿毒症患者的临床及研究工作 Objective To investigate the presence of gastric myoelectrical dysfunction in patients with uremia using surface electrogastrography. Methods 25 patients with uremic gastrointestinal symptoms and 25 healthy volunteers were enrolled in the study. Gastrogram was performed 30minutes before and after meal, and the test meal was 2008 32KJ (100g nutritional cereal, 200mL boiling water). Results The pre-meal frequency (DF), main power (DP) and normal rhythm percentage (N%) in healthy group were respectively 2. 9min -1 ± 0 1min -1 577bp ± 15 2bp and 90 9% ± 19%; after meal: 30min-1 ± 01min-1,21278bp ± 725bp (P <001), 926% ± 21%. The pre-meal DF, DP and N% of the uremia group were respectively 1.1 ± 1.0 ± 2.0min-1,6504bp ± 480bp and 47 ± 0 ± 39%, and the postprandial 12min-1 ± 02min-1,3648bp ± 245bp, 338% ± 31%. The above results were significantly different from the healthy group. Conclusions There is a disturbance of gastric electrogastrogram in patients with uremia. The disturbance of rhythm is mainly manifested in the obvious decrease of the percentage of normal rhythm and the decrease of postprandial power, suggesting abnormal gastric myoelectrical activity in patients with uremia. EGG as a non-invasive gastric motility test can be used for clinical and research work in patients with severe renal failure, uremia