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目的探讨甲状腺结节性疾病患者外周血中D-二聚体水平的变化及其临床意义。方法收集普外科住院患者120例,其中甲状腺良性疾病患者60例和甲状腺癌患者60例,采用Sysmex CA7000全自动凝血仪测定患者血浆D-二聚体水平,分析血浆D-二聚体水平与甲状腺癌临床病理特征的关系。结果甲状腺癌患者和甲状腺良性病变患者的D-二聚体水平比较差异无统计学意义(P>0.05)。甲状腺癌患者中,男性与女性、年龄≤44岁与年龄>44岁、不同病理类型之间、肿瘤直径≤1 cm与直径>1 cm、单侧与双侧、有腺外侵犯与无腺外侵犯、有淋巴结转移与无淋巴结转移、Ⅰ期~Ⅱ期与Ⅲ期~ⅥA期患者D-二聚体水平差异均无统计学意义(P>0.05)。结论甲状腺结节性疾病患者处于非高凝状态,血浆D-二聚体与甲状腺癌临床病理无密切相关性。
Objective To investigate the changes and clinical significance of D-dimer in peripheral blood of patients with thyroid nodular disease. Methods Totally 120 inpatients were enrolled in this study. Sixty patients with thyroid benign disease and 60 patients with thyroid cancer were enrolled in this study. Plasma D-dimer level was measured by Sysmex CA7000 automatic coagulation analyzer. The levels of plasma D-dimer and thyroid Relationship between clinicopathological characteristics and cancer. Results There was no significant difference in D-dimer between patients with thyroid cancer and thyroid benign lesions (P> 0.05). Thyroid cancer patients, male and female, aged ≤ 44 years and age> 44 years old, between different pathological types, tumor diameter ≤ 1 cm and diameter> 1 cm, unilateral and bilateral, with gland invasion and gonadal There was no significant difference in D-dimer levels between patients with stage Ⅰ-Ⅱ and stage Ⅲ-ⅥA with invasion, lymph node metastasis and non-lymph node metastasis (P> 0.05). Conclusions Patients with thyroid nodular disease are in non-hypercoagulable state, and there is no close correlation between plasma D-dimer and the clinicopathologic features of thyroid cancer.