尼莫地平属钙拮抗剂,其药理特性是有效调节细胞内钙的水平,使之保持正常的生理功能,对血管的作用尤其突出。主要用于防治缺血性脑血管疾病。由于该药属脂溶性药物,难洛于水,因此口服其生物利用度较低。本文对尼莫地平片及尼达尔片的溶出度进行了比较,发现由于尼达尔是采用固体分散技术经特殊工艺制成的尼莫地平,所以其溶出度比未经工艺改进的尼莫地平有显著提高。 Nimodipine is a calcium antagonist, its pharmacological properties is to effectively regulate the level of intracellular calcium to maintain normal physiological function, the role of the blood vessels is particularly prominent. Mainly used for the prevention and treatment of ischemic cerebrovascular disease. Because the drug is a fat-soluble drug, difficult to water, so its oral bioavailability is lower. In this paper, the dissolution of nimodipine tablets and nidasole tablets were compared and found that because of the use of solid dispersion technology, NIDODINE made by a special process of nimodipine, so its dissolution than the nimodipine without process improvement Significantly increased.