论文部分内容阅读
血清胆红素测定是诊断黄疸时最重要、最普通的肝功能检查。依据范登伯的重氮反应原理,用各种方法对TB(总胆红素)、DB(直接胆红素)和IB(间接胆红素)定量已广泛被进行。此法自Malloy和Evelyn最先提出后约经50年未变,一直沿用至今。但近年来,由于HPLC(高效液相层析法等带来的分离方法的进步,人们已了解到血清胆红素有与以前不同的病理生理意义,在黄疸的诊断、病程经过观察中有很大的实用性。本文以笔者等的研究成绩为中心,介绍这些血清胆红素新组分的临床意义及其产生机制。一、血清胆红素组分以血红蛋白为首的体内血红蛋白,和肝脏等脏器
Serum bilirubin determination is the most important and most common liver function test in the diagnosis of jaundice. Based on Vandenber’s diazo reaction principle, quantification of TB (total bilirubin), DB (direct bilirubin) and IB (indirect bilirubin) by various methods has been extensively conducted. This method has been in use since about 50 years after Malloy and Evelyn first proposed. However, in recent years, due to the progress of separation methods such as HPLC (high performance liquid chromatography, etc., it has been known that serum bilirubin has a different pathophysiological significance from the previous ones. In the diagnosis of jaundice, the course of the disease is observed Great practicality.In this paper, the author and other research results as the center, introduce the clinical significance of these serum bilirubin new components and its mechanism.One, serum bilirubin components to hemoglobin, such as hemoglobin, and the liver Organ