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目的:探讨左金丸加减联合四联疗法对幽门螺杆菌阳性功能性消化不良外来务工人员临床疗效及胃电参数的影响。方法:将我院收治的248例幽门螺杆菌阳性功能性消化不良外来务工人员随机分为两组;对照组124例采用四联疗法,而治疗组124例采用左金丸加减联合四联疗法。比较两组治疗前后临床疗效、胃电参数、幽门螺杆菌转阴率及生活质量的差异。结果:治疗组临床总有效率、治愈率分别为92.7%、34.7%高于对照组71.8%、17.7%,比较具有统计学差异(P<0.05);治疗后治疗组DF、DP、N水平升高,也高于同期对照组,比较均具有统计学差异(P<0.05);治疗2周后、4周后治疗组幽门螺杆菌转阴率分别为66.1%、90.3%高于对照组46.0%、71.0%,比较具有统计学差异(P<0.05);治疗后治疗组生活质量评分升高、也高于同期对照组,比较均具有统计学差异(P<0.05)。结论:左金丸加减联合四联疗法治疗幽门螺杆菌阳性功能性消化不良外来务工人员临床效果佳,其具有较高的临床有效率,幽门螺杆菌转阴率高,生活质量也得到改善,值得临床选择。
Objective: To investigate the effects of Zuojin Pills combined with quadruple therapy on clinical efficacy and gastric electrical parameters of Helicobacter pylori positive functional dyspepsia migrant workers. Methods: 248 cases of Helicobacter pylori positive functional dyspepsia workers admitted to our hospital were randomly divided into two groups; control group of 124 patients treated with quadruple therapy, while the treatment group of 124 patients treated with Zuojin Pill combined with quadruple therapy. The clinical efficacy, gastric parameters, Helicobacter pylori negative rate and quality of life before and after treatment were compared between the two groups. Results: The total clinical effective rate and cure rate in the treatment group were 92.7% and 34.7% respectively, which were significantly higher than those in the control group (71.8% and 17.7%, P <0.05) (P <0.05). After 2 weeks of treatment, the negative rates of Helicobacter pylori in the treatment group were 66.1% and 90.3% respectively, higher than those in the control group (46.0% , 71.0%, respectively (P <0.05). After treatment, the quality of life scores of the treatment group were also higher than those of the control group at the same period, with statistical significance (P <0.05). Conclusion: Zuojin pills combined with quadruple therapy plus quadruple therapy in the treatment of Helicobacter pylori positive functional dyspepsia migrant workers clinical effect is good, which has a high clinical efficiency, Helicobacter pylori negative conversion rate, quality of life has also been improved, it is worth Clinical choice.