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采用捕获和再捕获法调查１９９０～１９９９ 年间青岛地区２０ 岁以下１ 型糖尿病患者，用一步法序列特异性ＰＣＲ技术检测其ＨＬＡ－ＤＱβ基因型；并分析其发病年龄、年份、季节、遗传因素、诱因及并发症等。结果显示，青岛地区１ 型糖尿病患病率在国内属中等水平，男性好发于５～９ 岁及１０～１４ 岁，女性好发于１５～１９ 岁；ＨＬＡ－ＤＱβ链第５７ 位非门冬氨酸（ＮＡ）是易感基因，感染是重要的诱发因素；病程５年以上者应注意发现并防治微血管病变
The capture and recapture method was used to investigate the genotypes of HLA-DQβ in Qingdao patients under 20 years of age from 1990 to 1999. The HLA-DQβ genotypes were detected by one-step sequence-specific PCR. The age, year, season, genetic factors, Causes and complications. The results showed that the prevalence of Type 1 diabetes in Qingdao is moderate in China, with males predominantly aged 5 to 9 and 10 to 14 years old, and women predominantly aged 15 to 19 years old. HLA-DQβ chain 57 Amino acid (NA) is a susceptibility gene, infection is an important predisposing factor; duration of 5 years or more should pay attention to discover and prevent microvascular disease