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以痛刺激躯体神经引起清醒家兔反射性下颌运动作为痛反应的客观指标,观察用模似电针以兴奋支配“足三里”穴的腓神经的细纤维所致的镇痛效应,再用特异性鸦片受体阻断剂—纳洛酮,观察对细纤维镇痛作用的影响。结果表明,单纯电针兴奋Ⅲ类、Ⅳ类或ⅢⅣ类纤维对反射性下颌运动,其波幅下降平均在76%(Ⅲ类),73.9%(Ⅳ类)、79%(ⅢⅣ类),而电针加纳洛酮,其波幅下降平均在10.6(Ⅲ类)、12.5%(Ⅳ类)、10.7(ⅢⅣ类),两者相比,差异极为显著,这就表明电针兴奋细纤维所致的镇痛效应,可以被纳洛酮所反转,其反转率占实验列数的88.9%(Ⅲ类)、81.8%(Ⅳ类)及93.9%(ⅢⅣ类)、提示细纤维所致的镇痛效应与内源性鸦片样物质有关,即细纤维所致的镇痛作用主要是针刺镇痛的性质,而不像是应激所致的镇痛。
To stimulate the somatic nerve pain induced reflex mandibular movement of rabbits as an objective measure of pain response observed with analogue electro-acupuncture to control the “Zusanli” point of the peroneal nerve fiber fine analgesic effect, and then specific Effects of naloxone, a blocker of the opioid receptor, on the analgesic effect of fine fibers. The results showed that the amplitude of amplitude decreased only 76% (class Ⅲ), 73.9% (class Ⅳ) and 79% (Ⅲ Ⅳ) on pure electroacupuncture excited class Ⅲ, Ⅳ or ⅢⅣ, Needle plus naloxone, the average amplitude of the decline in 10.6 (class Ⅲ), 12.5% (Ⅳ class), 10.7 (Ⅲ Ⅳ class), the difference between the two is extremely significant, indicating that the needle excited by the fine fibers excited town The analgesic effect was reversible by naloxone, accounting for 88.9% (class III), 81.8% (class IV) and 93.9% (class IIIIV) of the experimental series, suggesting that fine fiber-induced analgesia Effects and endogenous opioid substances, namely, the analgesic effect caused by fine fibers is mainly the nature of acupuncture analgesia, rather than stress-induced pain.