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本文对28例恶性淋巴瘤患者(包括何杰金氏病,网细胞肉瘤和淋巴肉瘤)病变的淋巴结进行了染色体分析。9例做了染色体带型分析。结果表明大多数病人有染色体数目和结构异常。最常见的染色体数目改变是超二倍体,其次是三倍体,四倍体和亚二倍体。结构异常有四种类型:巨大亚中着丝粒染色体。巨大亚近端着丝粒染色体,14q~+染色体和着丝粒区不着色的染色体。最常见的染色体结构异常是巨大亚中着丝粒染色体,见于7例患者(其中6例是何杰金氏病)。在2例中被鉴定为1P~+染色体,其中1例是dir ins(1;4)(p36;q31—35)。巨大亚中着丝粒染色体以较高的频率出现在何杰金氏病中表明它是非随机性的染色体异常。本文的结果还表明染色体改变与恶性淋巴瘤的分型及病人对化疗的反应有一定关系。
In this paper, chromosomal analysis of lymph nodes from 28 patients with malignant lymphoma (including Hodgkin’s disease, cyto-sarcoma and lymphosarcoma) was performed. 9 cases of chromosome banding analysis. The results show that most patients have chromosomal number and structural abnormalities. The most common changes in the number of chromosomes are diploid, followed by triploid, tetraploid and sub-diploid. There are four types of structural abnormalities: giant sub-centromeric chromosomes. Large sub-centromeric centromere, 14q ~ + chromosomes and centromeric regions do not color chromosomes. The most common chromosomal structural abnormalities are the giant submetacentric chromosomes found in seven patients (six of them Hodgkin’s disease). In 2 cases it was identified as 1P ~ + chromosome, of which 1 was dir ins (1; 4) (p36; q31-35). Giant sub-centromeric chromosomes present in Hodgkin’s disease at higher frequencies indicate that it is a nonrandomized chromosomal abnormality. The results of this paper also show that chromosomal changes and malignant lymphoma and the patient’s response to chemotherapy has a certain relationship.