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目的:研究法舒地尔注射液治疗2型糖尿病患者下肢动脉病变的有效性和安全性。方法:诊断2型糖尿病下肢动脉病变患者治疗前询问相关症状,测定踝肱指数(ABl)、皮温,使用法舒地尔注射液60mg+0.9%氯化钠注射液250ml静脉注射14d(2周)后,再次观察症状,测定ABI、足背皮温。结果:50例患者中无严重不良反应,6例有轻度面部潮红,3例有轻度头痛症状,自行缓解无需处理。50例患者平均踝肱指数(ABl)治疗前0.76±0.07,治疗后0.91±0.05(P<0.05),足背温治疗前30.2±1.3(℃),治疗后31.7±0.9(℃)(P<0.05)。结论:法舒地尔注射液在治疗糖尿病下肢动脉不病变短期治疗有效,在治疗期间未发现严重不良反应。
Objective: To study the efficacy and safety of fasudil injection in the treatment of lower extremity arterial disease in type 2 diabetic patients. Methods: The patients with lower extremity arterial disease in type 2 diabetes were asked about the symptoms before treatment. The ankle brachial index (ABl) and skin temperature were measured. The patients were given Fasudil 60mg and 0.9% sodium chloride 250ml intravenously for 14 days ), Observe the symptoms again, determine ABI, dorsal skin temperature. Results: There was no serious adverse reactions in 50 patients, 6 cases had mild facial flushing, 3 cases had mild headache symptoms, relieved without treatment. The mean ankle brachial index (ABI) of 50 patients was 0.76 ± 0.07 before treatment, 0.91 ± 0.05 after treatment (P <0.05), 30.2 ± 1.3 (℃) before treatment and 31.7 ± 0.9 (℃) after treatment 0.05). Conclusion: Fasudil injection is effective in short-term treatment of diabetic lower extremity arterial disease. No serious adverse reactions were found during the treatment.