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本研究在中医药理论指导下,用多种因素造模方法塑造了脾阳虚证大鼠模型,将Wister大鼠随机分为6组,每组10只,空白对照组、模型组、附子粳米汤大剂量组、附子粳米汤中剂量组、附子粳米汤小剂量组、消炎痛组,并分别给予相应的汤剂灌胃。通过分子生物学理论技术,对脾阳虚大鼠血清中白介素“-”1β(IL-1β)、肿瘤坏死因子“-”α(TNF-α)进行检测。研究结果显示:附子粳米汤能明显降低其血清中IL-1β、TNF-α的含量,并存在量效关系,这可能是治疗脾阳虚腹痛的作用机制之一,从而度揭示了附子粳米汤的部分药理机制。
In this study, under the guidance of the theory of traditional Chinese medicine, a rat model of spleen and Yang deficiency was modeled using a variety of factors modeling methods. Wister rats were randomly divided into 6 groups, 10 in each group, blank control group, model group, aconite sticky rice. The high-dose soup group, aconite glutinous rice soup medium-dose group, aconite glutinous rice soup small dose group, indomethacin group, and were given the corresponding decoction gavage. The serum IL-1β and TNF-α levels in spleen yang deficiency rats were detected by molecular biology techniques. The research results show that: Aconite decoction can significantly reduce the serum IL-1β, TNF-α content, and there is a dose-effect relationship, which may be one of the mechanisms of the treatment of spleen-yang deficiency abdominal pain, thus revealing Aconite Decoction The part of the pharmacological mechanism.