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１９９８年广东某戒毒所ＨＩＶ阳性感染者的血样，经ＰＣＲ扩增未培养细胞内ＨＩＶ前病毒基因并对Ｃ２－Ｖ３区进行测序和分析，发现两例感染者与巴西Ｆ亚型毒株ＢＺ１６３的基因离散率小于４％；Ｎｅｉｇｈｂｏｒ－ｊｏｉｎｉｎｇ系统树表明，它们与Ｆ亚型聚在一起；通过异源双链泳动技术分析法（ＨＭＡ）分析，这两例感染者与Ｆ亚型形成明显的异源二聚体。上述各项研究结果表明，Ｆ亚型ＨＩＶ－１已传入我国。
In 1998, a sample of HIV-positive persons in a drug rehabilitation center in Guangdong was used to amplify the HIV-1 previrus gene in non-cultured cells by PCR. The C2-V3 region was sequenced and analyzed. Two cases of infection were found to be associated with the BZ163 The genetic divergence was less than 4%; the Neighbor-joining phylogenetic tree indicated that they were clustered with the F subtype; and the two cases were significantly different from the F subtype by the heteroduple chain-motive assay (HMA) Heterodimers. The above results show that F subtype HIV-1 has been introduced into our country.