台湾大学的Kao等一项研究表明,HBV基因型C与较高频率的核心启动子突变以及对α干扰素的反应率较低相关。在HBV基因型之间可能存在致病性上的差异。他们的研究结果表明,HBV基因型C感染的病人血清转氨酶水平较高,核心启动子突变的频率也较高。基因型B和C感染的病人对于扰素治疗的反应率分别为41％和15％。血清转氨 A study by Kao et al. At National Taiwan University found that HBV genotype C was associated with higher frequencies of core promoter mutations and lower response rates to interferon alpha. There may be pathogenic differences between HBV genotypes. Their findings suggest that patients with HBV genotype C have a higher serum aminotransferase level and a higher frequency of core promoter mutations. Response rates for interferon-treated patients with genotype B and C infections were 41% and 15%, respectively. Serum to ammonia