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急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)是临床常见的一种急性、进行性缺氧性呼吸衰竭,其肺纤维化发生率高。ARDS肺纤维化发生机制复杂,其中与上皮细胞再生障碍、纤维蛋白代谢异常、成纤维细胞增生及表型的改变、凝血反应增强和纤溶活性减弱、血管生成反应增强、炎症反应的影响及MMPs及其抑制物(TIMP)的作用密切相关。由于ARDS预后与肺纤维化程度密切相关,故针对ARDS早期纤维增生的治疗是改善ARDS预后的重要措施。
Acute respiratory distress syndrome (acute respiratory distress syndrome, ARDS) is a common clinical acute, progressive hypoxic respiratory failure, the incidence of pulmonary fibrosis is high. ARDS pulmonary fibrosis mechanism is complicated, including epithelial cell aplasia, abnormal fibrin metabolism, fibroblast proliferation and phenotype changes, increased coagulation reaction and fibrinolytic activity, increased angiogenesis, inflammatory response and MMPs And its inhibitor (TIMP) is closely related to the role. As the prognosis of ARDS is closely related to the degree of pulmonary fibrosis, the treatment of early ARDS is an important measure to improve the prognosis of ARDS.