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目的:通过分析凝固酶阴性葡萄球菌(CNS)临床分布及耐药情况,为临床合理用药提供依据。方法:采用ATB-Expression细菌鉴定及药敏系统对2006年1月~2009年1月门诊及住院患者各类标本分离到的CNS进行的鉴定和药敏实验进行回顾性分析。结果:共检出286株11种CNS菌,广泛存在于14类临床标本中;其中,呼吸道、泌尿道标本中CNS的分离率最高为32.4%、23.2%。以表皮葡萄球菌、溶血葡萄球菌和缓慢葡萄球菌为主。其耐药性以青霉素、红霉素、苯唑西林最高,分别为96%、94%、81%;对氯洁霉素、第二代喹诺酮、左氟沙星耐药性次之,也大于70%;对呋西地酸、替考拉宁、米诺环素、喹奴普叮-达福普叮耐药率低,小于10%,未检出对万古霉素耐药菌株。结论:临床应关注CNS的感染,控制该类感染并应积极进行病原菌学监测,根据药敏结果选用抗菌药物,延缓其耐药性的产生和蔓延。
Objective: To provide a basis for clinical rational drug use by analyzing the clinical distribution and drug resistance of coagulase-negative staphylococci (CNS). Methods: The ATB-Expression bacteria identification and drug susceptibility system were used to identify the CNS isolated from all kinds of outpatients and hospitalized patients from January 2006 to January 2009 and drug susceptibility testing. Results: A total of 286 strains of 11 CNS were detected and found in 14 clinical samples. Among them, the highest rates of CNS isolation in respiratory tract and urinary tract were 32.4% and 23.2%, respectively. Staphylococcus epidermidis, Staphylococcus haemolyticus and Staphylococcus aureus-based. Its resistance to penicillin, erythromycin, oxacillin highest, respectively, 96%, 94%, 81%; chlorine clindamycin, second-generation quinolone, levofloxacin resistance followed by greater than 70%. The rates of resistance to fuxiidic acid, teicoplanin, minocycline and quinuptyline-dalfluid were low, less than 10%. No vancomycin-resistant strains were detected. Conclusions: CNS infection should be paid attention to in clinical practice. Infection should be controlled and pathogensis should be actively monitored. Antibacterial drugs should be selected according to drug susceptibility results to delay the emergence and spread of drug resistance.