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采用一种新设计的电解池,利用三电极系统研究了相比为1(r=Vo/Vw)时可质子化药物在水/1,2-二氯乙烷界面(W/DCE)上的转移反应,确定了它们的亲油性.该系统是将含有支持电解质的水溶液滴在银/氯化银电极上,然后将1,2-二氯乙烷溶液覆盖在水溶液的表面,再与有机相参比电极和对电极构成常规的三电极系统.由不同pH值下测得的循环伏安图计算出了阿米替林、苯海拉明和苯海索3种药物离子在W/DCE上的标准离子分配系数、标准离子转移电位及标准离子转移吉布斯自由能等.由实验结果构建的离子分布图可用来预测和解释可离子化物质在两互不相溶溶液界面上的转移反应机理等.
A newly designed cell was used to study the effect of protonatable drug on the water / 1,2-dichloroethane interface (W / DCE) at a ratio of 1 (r = Vo / Vw) Transfer reaction, to determine their lipophilicity.The system is a solution containing a supporting electrolyte drops on silver / silver chloride electrode, and then 1,2-dichloroethane solution covering the surface of the aqueous solution, and then with the organic phase The reference electrode and the counter electrode constitute a conventional three-electrode system.The cyclic voltammograms measured at different pH values calculated that the three kinds of drug ions of amitriptyline, diphenhydramine and trihexyphenylate are on W / DCE Standard ion partition coefficient, standard ion transfer potential, and standard ion transfer Gibbs free energy, etc. The ion profile constructed from the experimental results can be used to predict and explain the transfer reaction mechanism of ionizable species at the interface between two mutually immiscible solutions Wait.