青蒿素的衍生物如蒿甲醚和青蒿琥酯,现已广泛地用于疟疾治疗;在东南亚地区,因那里的恶性疟原虫对其它常用抗疟药普遍产生了抗药性,应用更广泛。但有学者报道,用蒿甲醚剂量较大时可引起中枢神经系统的损害。为此,本文作者对青蒿素的衍生物用大鼠进行了神经病理学和体外试验研究。 Derivatives of artemisinin, such as artemether and artesunate, are now widely used in the treatment of malaria; in South-East Asia, Plasmodium falciparum there is generally resistant to other commonly used antimalarials and is more widely used . However, some scholars have reported that with a large dose of artemether can cause damage to the central nervous system. To this end, the author of artemisinin derivatives of rat neuropathology and in vitro studies.