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采用随机双盲交叉的方法，对４６例动态心电图监测证实为无症状性心肌缺血的冠心病患者，观察美托洛尔和硝苯地平的抗缺血作用。结果发现，这两类药物对减少无症状性心肌缺血发作的平均数量和时间均有效，但以美托洛尔最明显，两组间比较有极显著性差异（Ｐ＜０．００１），而且美托洛尔抗缺血的持续时间长于硝苯地平。因此，美托洛尔可作为无症状性心肌缺血的首选药物。
46 cases of coronary heart disease confirmed by ambulatory electrocardiogram monitoring were asymptomatic myocardial ischemia. The anti-ischemic effects of metoprolol and nifedipine were observed. The results showed that these two drugs were effective in reducing the average number and duration of episodes of asymptomatic myocardial ischemia, but metoprolol was the most significant difference between the two groups (P <0.001) And metoprolol anti-ischemic duration longer than nifedipine. Therefore, metoprolol can be used as the drug of choice for asymptomatic myocardial ischemia.