不同原因引起的肺动脉高压(简称肺高压)都具有共同的特征性病理改变,即血管收缩、血管重塑及原位血栓形成。血栓调节蛋白(TM)是机体中最重要的抗凝因子,在维持正常凝血功能及维持血液的流动性等方面发挥重要作用。研究发现肺高压时血浆 TM 水平降低,提示 TM 可能在肺高压形成过程中发挥作用。本研究采用 ELISA、RT-PCR、Western Blot 等方法检测大鼠血浆 TM 水平、观察 TM mRNA 及其蛋白在野百合碱 Pulmonary hypertension caused by different causes (referred to as pulmonary hypertension) have a common characteristic pathological changes, namely vasoconstriction, vascular remodeling and in situ thrombosis. Thrombomodulin (TM) is the most important anticoagulant factor in the body and plays an important role in maintaining normal blood coagulation and maintaining blood fluidity. The study found that plasma levels of TM decreased pulmonary hypertension, suggesting that TM may play a role in the formation of pulmonary hypertension. In this study, serum levels of TM were measured by ELISA, RT-PCR, Western Blot and other methods to observe TM mRNA and protein in monocrotyl