Two new styryllactones, iso-goniopypyrone and 8-acetyl-9-deoxygoniopypyrone, were isolated from the roots of Goniothalamus cheliensis. Their structure were elucidated on the basis of spectroscopic and chemical evidences. Two new styryllactones, iso-goniopypyrone and 8-acetyl-9-deoxygoniopypyrone, were isolated from the roots of Goniothalamus cheliensis. Their structure was elucidated on the basis of spectroscopic and chemical evidences.