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目的:研制一种局部应用治疗小儿湿疹的制剂。方法:按凝胶剂制备工艺制备了诺氟沙星锌凝胶剂;建立了性状、鉴别、酸碱度、含量测定等质控方法,并进行了体外抑菌实验。结果:以紫外分光光度法测定诺氟沙星锌凝胶剂的含量,平均回收率为100.03%,RSD为1.67%;稳定性良好。结论:该制剂制备工艺可行,性质稳定,质控方法简单可靠。
Objective: To develop a topical application of pediatric eczema preparations. Methods: Norfloxacin zinc gel was prepared according to the preparation method of gelatin. Quality control methods such as traits, identification, pH, content determination were established, and antibacterial activity was tested in vitro. Results: The content of norfloxacin zinc gel was determined by UV spectrophotometry with the average recovery of 100.03% and RSD of 1.67%. The stability was good. Conclusion: The preparation process is feasible, stable in nature and the quality control method is simple and reliable.