论文部分内容阅读
目的探讨白介素-6(IL-6)、C-反应蛋白(CRP)及D-二聚体在慢性阻塞性肺疾病(COPD)急性加重期中的变化与意义。方法检测48例慢性阻塞性肺疾病急性加重期患者治疗前后和43例健康对照组血清中IL-6,CRP和D-二聚体的水平。结果慢性阻塞性肺疾病急性加重期中IL-6,CRP和D-二聚体治疗前的水平均显著高于治疗后及健康对照组,差别具有显著性意义(P<0.05),D-二聚体与动脉血氧分压(PaO2)成负相关(r=-0.567,P<0.05),与(PaCO2)成正相关(r=0.683,P<0.05)。结论 IL-6与CRP联合检测可作为早期判断COPD急性加重的敏感指标,及时纠正缺氧、解痉及适当的给予抗凝药物治疗,有助于改善患者临床预后。
Objective To investigate the changes and significance of interleukin-6 (IL-6), C-reactive protein (CRP) and D-dimer in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods Serum levels of IL-6, CRP and D-dimer in 48 patients with COPD at acute exacerbation were measured before and after treatment and in 43 healthy controls. Results The levels of IL-6, CRP and D-dimer before and after acute exacerbation of chronic obstructive pulmonary disease were significantly higher than those of healthy controls (P <0.05) Body and arterial partial pressure of oxygen (PaO2) was negatively correlated (r = -0.567, P <0.05), and (PaCO2) was positively correlated (r = 0.683, P <0.05). Conclusion The combined detection of IL-6 and CRP can be used as a sensitive indicator of acute exacerbation of COPD in early stage. It can correct hypoxia, antispasmodic and appropriate anticoagulant therapy in time to improve the clinical prognosis of patients.