超微结构病理从亚细胞水平反映了病变的特点和性质,较之光学显微镜(光镜)下的细胞病理有了很大的提高,两者结合应用可以大大提高病理诊断水平,特别是肿瘤病理诊断。当然大多数肿瘤的病理诊断用光镜检查能得到解决,但仍有一些(约8％)较疑难的病例需要配合电子显微镜(电镜)才能作出诊断,尚有3％病例则需要依靠电镜检查才能确诊。足见电镜检查对解决疑难诊断是能起到一定的作用。但一般常规病理标本大多已经过福尔马林固定,石蜡包埋,亚微结构受到一定程度的影响,能否再进行回顾性电镜观察,应用于病理诊断,是病理工作者迫切需要解决的问题,近年来不少学者已作了可喜 The ultrastructural pathology reflects the characteristics and properties of the lesions from the subcellular level, and greatly improves the cytopathology under the light microscope (light microscope). The combination of the two can greatly improve the pathological diagnosis level, especially the tumor pathology. diagnosis. Of course, the pathological diagnosis of most tumors can be resolved with light microscopy, but there are still some (about 8%) more difficult cases that need to cooperate with electron microscopy (electron microscopy) to make a diagnosis, and 3% of cases need to rely on electron microscopy Confirmed. The observation of electron microscopy can play a role in solving difficult diagnosis. However, most conventional pathological specimens have been formalin-fixed, paraffin-embedded, and sub-microstructures have been affected to some extent. Whether they can be retrospectively observed by electron microscopy and applied to pathological diagnosis is an urgent problem for pathologists. In recent years, many scholars have made gratifying