Objective: We aimed to study the appropriate posture of peripherally inserted central catheter(PICC) patients, to reduce the incidence of internal jugular vein heterotopia. Methods: From 2009 to 2013, a total of 290 cases with PICC were enrolled in our study. They were divided into two groups. The patients in control group took regular position, which mean prostration, upper limb of tube side was abduction 90°, head moved to puncture side in order to block the internal jugular vein. On the basis of conventional body position putting, posture of patients in observation group was improved, the head remain neutral, and had 180° angle with trunk longitudinal axis, not favor any side. After ensuring the upper limb abduction, had 90° angle with the trunk, then catheter was inserted slowly. The jugular venous catheter heterotopia rate was judged by X-ray results. Results: The jugular venous catheter heterotopia rate of control group and observation was 12.8% and 0.68%, respectively. The difference between two groups was statistically significant(P < 0.01). Conclusion: The body posture improvement can prevent discomfort of patients and reduce the jugular venous catheter heterotopia rate of PICC. Objective: We aimed to study the appropriate posture of peripherally inserted central catheter (PICC) patients, to reduce the incidence of internal jugular vein heterotopia. Methods: From 2009 to 2013, a total of 290 cases with PICC were enrolled in our study. were divided into two groups. The patients in control group took regular position, which mean prostration, upper limb of tube side was abduction 90 °, head moved to puncture side in order to block the internal jugular vein. putting, posture of patients in observation group was improved, the head remain neutral, and had 180 ° angle with trunk longitudinal axis, not favor any side. After ensuring the upper limb abduction, had 90 ° angle with the trunk, then catheter was was inserted slowly. The jugular venous catheter heterotopia rate was judged by X-ray results. Results: The jugular venous catheter heterotopia rate of control group and observation was 12.8% and 0.68% respectively. The di fference between two groups was statistically significant (P <0.01). Conclusion: The body posture improvement can prevent discomfort of patients and reduce the jugular venous catheter heterotopia rate of PICC.