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本调查旨在了解2010年云南省昭通市1株脊髓灰质炎Ⅱ型疫苗衍生毒株(Vaccine-derived poliovirus,VDPV)引起的病例的流行病学特征、该病例的排毒情况及其周围健康儿童的肠道病毒(EV)携带情况和病毒型别特征。在该病例的发生地进行现场流行病学调查,连续采集病例粪便标本,采集密切接触者及病例居住地健康儿童粪便标本进行病毒分离和型别鉴定。经省级专家组最终分类诊断为VDPV病例;实验室结果显示病例标本中未再检出VDPV;密切接触者及周围健康儿童标本中均未检测到脊灰疫苗株病毒及VDPV,AFP病例入户主动搜索未发现类似病例,表明该病毒未在当地造成循环;在健康儿童中检测到NPEV 21株,病毒携带率为20.0%;经VP1区核苷酸序列测定,21株NPEV分别属于HEV-A组(11株,3个血清型,占52.4%)和HEV-B组(10株,4个血清型,47.6%)。
The purpose of this survey is to understand the epidemiological characteristics of a case of poliovirus type 1 (VDPV) caused by a 2010 poliovirus in Zhaotong, Yunnan Province. The detoxification of this case and its surrounding healthy children Enterovirus (EV) carrier and virus type characteristics. Epidemiological investigation was conducted at the site of the case, continuous collection of stool samples, and collection of close contacts and stool samples from healthy children living in the area for virus isolation and type identification. VDPV was finally diagnosed by the provincial expert group; VDPV was not detected in the laboratory samples in laboratory; polio vaccine virus and VDPV were not detected in close contacts and surrounding healthy children, and cases of AFP In the active search, no similar cases were found, indicating that the virus did not cause circulation in the local; 21 NPEV strains were detected in healthy children, the virus carrying rate was 20.0%; 21 NPEV belonged to HEV-A (11 strains, 3 serotypes, accounting for 52.4%) and HEV-B group (10 strains, 4 serotypes, 47.6%).