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白细胞介素-6(Interleukin-6,IL-6)是一种细胞因子,参与免疫调节、急性期反应、防御和造血等多种生物效应。在正常表达的情况下,可发挥积极的作用,过度表达又会导致机体的病理损伤。近年来,一直是医药学界关注的焦点之一。1 IL-6的结构和基因表达的调节 人白细胞介素-6(hIL-6)由212个氨基酸组成,含有2个N糖基化位点。小鼠IL-6由211个氨基酸组成,不含N糖基化位点,而含一些O糖基化位点。在蛋白质水平,人与小鼠IL-6的同源性为42％。人、小鼠IL-6的4个半脱氨酸残基是保守的,含半脱氨酸区
Interleukin-6 (IL-6) is a cytokine involved in many biological effects such as immune regulation, acute phase response, defense and hematopoiesis. In the case of normal expression, can play an active role, over-expression can lead to the body’s pathological damage. In recent years, it has always been one of the focuses of medical scholarship. 1 Structure and Gene Expression Regulation of IL-6 Human interleukin-6 (hIL-6) consists of 212 amino acids and contains two N-glycosylation sites. Mouse IL-6 consists of 211 amino acids, contains no N-glycosylation sites and some O-glycosylation sites. At the protein level, human-mouse IL-6 has a homology of 42%. The 4 hemi-desaturase residues of human and mouse IL-6 are conserved, containing the half-amino acid region