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Objective:To investigate the relationship between NAD(P)H:quinone oxidoreductase 1(NQO1) C609T polymorphism and colon cancer risk in farmers from western region of Inner Mongolia.Methods:Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) was performed to analyze NQO1 C609T polymorphism from 160 healthy controls and 76 colon cancer patients.Results:Among the colon cancer patients,the incidence of NQO1 T allele(53.29%) was significantly higher than it in control group(33.75%,P<0.001).The individuals with NQO1 T allele had higher risk [2.239(95% CI:1.510-3.321) times] to develop colon cancer than individuals with NQO1 C allele.The incidence of NQO1(T/T)(34.21%) in colon cancer patients was higher than that in control group(15.62%,P<0.001).Odds ratios(OR) analysis suggested that NQO1(T/T) and NQO1(T/C) genotype carriers had 3.813(95% CI:1.836-7.920) times and 2.080(1.026-4.219) times risk compared with wild-type NQO1(C/C) gene carriers in developing colon cancer.Individuals with NQO1(T/T) genotype had 2.541(95% CI:0.990-6.552) times,3.713(95% CI:1.542-8.935) times,and 3.471(95% CI:1.356-8.886) times risk than individuals with NQO1(T/C) or NQO1(C/C) genotype in welldifferentiated,moderately-differentiated,and poorly-differentiated colon cancer patients,respectively.Conclusions:NQO1 gene C609T could be one of risk factors of colon cancer in farmers from western region of Inner Mongolia.
Objective: To investigate the relationship between NAD(P)H:quinone oxidoreductase 1(NQO1) C609T polymorphism and colon cancer risk in farmers from western region of Inner Mongolia.Methods:Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) was Performed to analyze NQO1 C609T polymorphism from 160 healthy controls and 76 colon cancer patients.Results:Among the colon cancer patients,the incidence of NQO1 T allele(53.29%) was significantly higher than it in control group(33.75%,P<0.001) .The individuals with NQO1 T allele had higher risk [2.239(95% CI:1.510-3.321) times] to develop colon cancer than individuals with NQO1 C allele.The incidence of NQO1(T/T)(34.21%) in colon cancer Patients were higher than that in control group(15.62%,P<0.001).Odds ratios(OR) analysis suggested suggested that NQO1(T/T) and NQO1(T/C) genotype carriers had 3.813(95% CI:1.836-7.920 ) times and 2.080(1.026-4.219) times risk compared with wild-type NQO1(C/C) gene carriers in developing colon cancer.I Ndividuals with NQO1(T/T) genotype had 2.541(95% CI:0.990-6.552) times, 3.713(95% CI:1.542-8.935) times, and 3.471(95% CI:1.356-8.886) times risk than individuals with NQO1(T/C) or NQO1(C/C) genotype in welldifferentiated, moderately-differentiated, and poorly-differentiated colon cancer patients,respectively.Conclusions:NQO1 gene C609T could be one of risk factors of colon cancer in farmers from western region Of Inner Mongolia.