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目的研究小儿肾脏疾病血、尿内皮素（ＰＥＴ、ＵＥＴ）的水平及其相互关系。方法采用同位素放免方法检测了肾病综合征（ＮＳ），肾小球肾炎（ＧＮ），肾功能衰竭（ＲＦ）共７２例患儿血及尿中ＥＴ，血心钠素（ＡＮＰ）水平。结果ＮＳ，ＧＮ，ＲＦ三组的ＰＥＴ及ＵＥＴ值明显高于对照组，尤其ＲＦ组（Ｐ＜００５，Ｐ＜０．０１）。ＡＮＰ值在ＧＮ组和ＲＦ组明显高于对照组（Ｐ＜００１）。８例ＡＲＦ患儿恢复期血ＥＴ水平下降，６例ＣＲＦ患儿虽经治疗，但血ＥＴ水平不降或上升。结论ＥＴ在小儿肾脏疾病发病机理及病情进展中可能起重要作用，其值高低与病情严重程度及预后有关。
Objective To study the levels of blood and urinary endothelin (PET, UET) and their correlation in children with renal disease. Methods Serum and urinary levels of ET and ANP were measured in 72 children with nephrotic syndrome (NS), glomerulonephritis (GN) and renal failure (RF) by radioimmunoassay. Results The PET and UET values in NS, GN and RF groups were significantly higher than those in control group, especially in RF group (P <005, P <0.01). ANP values were significantly higher in the GN and RF groups than in the control group (P <001). 8 patients with ARF convalescent blood levels of ET decreased, 6 cases of CRF despite treatment, but the blood level of ET does not decrease or increase. Conclusions ET may play an important role in the pathogenesis and progression of pediatric kidney disease. The value of ET may be related to the severity and prognosis.