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骨骼疾病如骨质疏松症是由于骨吸收(破骨细胞介导)和骨形成(成骨细胞介导)的自然过程之间的失衡所致。目前多数药物旨在减少骨的再吸收率以纠正这种不平衡,但破骨细胞和成骨细胞活性之间的关联被破坏,也可能引起新骨形成的减少。最近Takayanagi等确定了破骨细胞和成骨细胞的双重调节因子——
Bone disorders such as osteoporosis are due to an imbalance between the natural processes of bone resorption (osteoclast-mediated) and bone formation (osteoblast-mediated). Most drugs are currently aimed at reducing bone resorption to correct this imbalance, but the link between osteoclast and osteoblast activity is disrupted and may also lead to a decrease in new bone formation. Recently Takayanagi et al identified osteoclasts and osteoblasts as double regulators -