在合成三环苯并二氮杂(艹卓)过程中发现中间体7-苯甲酰吲哚满(1)在动物实验中呈现与保泰松可相比拟的抗炎作用。但与它关连的8-苯甲酰1,2,3,4-四氢异喹啉,2-氨基二苯酮和2-甲氨基二苯酮都无活性,因此活性作用与其代谢产物有关。通常氨基或环氨类化合物在体内经氨基α位氧化转变为氨基酸,从而推测(1)的 The intermediate 7-benzoylindoline (1) was found in the synthesis of tricyclic benzodiazepines to show comparable anti-inflammatory properties to phenylbutazone in animal experiments. However, the related 8-benzoyl 1,2,3,4-tetrahydroisoquinoline, 2-aminobenzophenone and 2-methylaminobenzophenone are inactive, so the activity of its metabolites. Often the amino or cyclic amino compounds are converted to amino acids at the α-position of the amino group in vivo to speculate that (1)