日前,美国《自然》杂志(Nature)上发表了我国专家的一项新研究。中国科学院上海生命科学研究院裴钢院士领衔的研究组,发现2型糖尿病模型小鼠体内β休止蛋白2表达显著下调,揭示了胰岛素抵抗及2型糖尿病发生的一种新机制。研究者认为,β休止蛋白2及其与胰岛素受体的复合体有望成为研发胰岛素抵抗等代谢疾病药物的新靶点。 Recently, a new study by our experts was published in the U.S. Nature. A study led by Academician Pei Gang of Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences found that expression of β resting protein 2 was significantly downregulated in type 2 diabetic mice, revealing a new mechanism of insulin resistance and type 2 diabetes. Researchers believe β-arrestin 2 and its complex with insulin receptor are expected to become new targets for the development of drugs for metabolic diseases such as insulin resistance.