大多数非胰岛素依赖型糖尿病人对胰岛素的生物作用具有拮抗,这是引起糖尿病的主要因素之一。胰岛素作用的第一步是与其受体结合,因此,胰岛素受体的功能缺损便成为糖尿病患者产生胰岛素拮抗的原因。当胰岛素与受体的细胞外区域结合时,受体便开始进行自磷酸化,与受体的细胞内区域有关的酪氨酸激酶被活化,从而激发靶细胞中的生物 Most people with non-insulin-dependent diabetes have antagonistic effects on the biological role of insulin, one of the major causes of diabetes. The first step in the action of insulin is to bind to its receptor, so the functional impairment of the insulin receptor becomes the cause of insulin resistance in diabetic patients. When insulin binds to the extracellular domain of the receptor, the receptor begins to autophosphorylate and the tyrosine kinase associated with the intracellular domain of the receptor is activated, thereby activating the organism in the target cell