本文用超排卵技术使雌性小鼠排卵,排卵前用药物或化学物处理后与雄性小鼠交配,以小鼠卵母细胞(MⅡ)及第一次分裂合子雌原核染色体非整倍体及结构畸变为指标,研究其诱变作用。结果表明,对照组小鼠卵母细胞(MⅡ)及第一次分裂合子均未发现有染色体非整倍体及结构畸变。处理组中,环磷酰胺和乙醇可诱发小鼠卵母细胞(MⅡ)及第一次分裂合于雌原核染色体非整倍体率增加,醋酸棉酚、氯氮平、苯妥英钠及安定则无明显影响。 In this paper, ovulation and ovulation were induced by ovulation in ovariectomized mice and treated with drugs or chemicals before ovulation. Male mice were mated with mouse oocytes (M Ⅱ) and the first mitotic zygote Distortion as an indicator to study its mutagenic effect. The results showed that there were no chromosomal aneuploidy and structural aberrations in control mouse oocytes (M Ⅱ) and the first mitotic. Treatment group, cyclophosphamide and ethanol can induce mouse oocytes (M Ⅱ) and the first split in the female prolactin chromosome aneuploidy rate increases, gossypol acetate, clozapine, phenytoin sodium and stability and no Clearly affected.