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[目的］检测食管癌CD34和PCNA的表达，探讨微血管密度和细胞增殖状态与食管癌临床病理的关系。[方法］运用免疫组化法对30例食管癌手术标本进行CD34和PCNA检测。［结果］CD34标记的微血管在食管癌中呈异质性。高分化、早期食管癌微血管密度明显低于低分化、中晚期食管癌（P＜0.05和P＜0.01），同样PCNA标记指数在高分化和早期食管癌中明显较低（P＜0.05和P＜0.01）。存活5年以上与5年以内复发死亡者之间微血管密度和PCNA指数差异有显著性意义（P＜0．01）。［结论］微血管定量和PCNA对食管癌预后判断有重要意义。
[Objective] To detect the expression of CD34 and PCNA in esophageal carcinoma and explore the relationship between microvessel density and cell proliferation status and clinical pathology of esophageal carcinoma. [Methods] Immunohistochemical method was used to detect CD34 and PCNA in 30 specimens of esophageal cancer. [Results] CD34-labeled microvessels were heterogeneous in esophageal cancer. The microvessel density of well-differentiated and early esophageal cancer was significantly lower than that of poorly-differentiated and advanced esophageal cancer (P<0.05 and P<0.01). The same PCNA-labeled index was significantly lower in well-differentiated and early esophageal cancer (P<0.05 and P<0.05). 0.01). There was a significant difference in microvessel density and PCNA index between those who survived more than 5 years and those who relapsed within 5 years (P<0.01). [Conclusion] Microvessel quantification and PCNA have important significance for the prognosis of esophageal cancer.