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目的观察大剂量纳络酮辅助治疗重度毒鼠强中毒的疗效。方法将重度毒鼠强中毒患者127例按昏迷程度分为中毒伴浅昏迷组、中毒伴深昏迷组。两组分别随机分为对照组、治疗组和常规治疗组,三组基础治疗相同。治疗组加用大剂量纳络酮,常规治疗组加入常规剂量纳络酮,而对照组不用。结果与对照组和常规治疗组相比,中毒伴浅昏迷患者治疗组仅苏醒时间明显缩短,具有显著统计学意义(P<0.01)。而中毒伴深昏迷患者治疗组死亡人数及中毒性脑病后遗症均明显减少,苏醒时间也缩短,具有显著统计学意义(P<0.01)。结论应用大剂量纳络酮降低了重度毒鼠强中毒患者死亡率,明显改善了预后,缩短了昏迷时间。
Objective To observe the efficacy of high-dose naloxone in the treatment of severe tetramine poisoning. Methods A total of 127 cases of severe tetramine poisoning patients were divided into coma with light coma and poisoning with deep coma according to the degree of coma. Two groups were randomly divided into control group, treatment group and conventional treatment group, three groups of the same basic treatment. The treatment group with high-dose naloxone, conventional treatment group to join the conventional dose of naloxone, while not in the control group. Results Compared with the control group and the conventional treatment group, the recovery time of the treatment group with poisoning and shallow coma was significantly shortened, with significant statistical significance (P <0.01). The number of deaths and toxic sequelae in treatment group with poisoning and deep coma were significantly decreased, recovery time shortened, with significant statistical significance (P <0.01). Conclusion The application of high-dose naloxone reduces the mortality of patients with severe tetramine poisoning, significantly improves the prognosis and shortens the coma time.