目的　探讨卵巢浆液性腺癌nm2 3蛋白的表达及其与预后的关系。　方法　应用S P免疫组化技术 ,检测 6 6例卵巢浆液性腺癌nm2 3蛋白的表达。　结果　 6 6例卵巢浆液性腺癌中 ,nm2 3蛋白表达阳性率 6 5 2 % ,而Ⅰ、Ⅱ、Ⅲ级肿瘤中nm2 3表达率分别为 89 5 %、6 6 7%、4 3 5 %。nm2 3蛋白表达阳性率随病理分级增高而降低 ,Ⅰ级与Ⅲ级、Ⅰ级加Ⅱ级与Ⅲ级比较有显著性差异 (P <0 0 5 ) ,且与肿瘤大小、转移及预后相关 (P <0 0 1、P <0 0 5 )。　结论　nm2 3蛋白检测有助于判断卵巢浆液性腺癌恶性程度及预后 Objective To investigate the expression of nm23 protein in ovarian serous adenocarcinoma and its relationship with prognosis. Methods S P immunohistochemistry was used to detect the expression of nm23 protein in 66 cases of ovarian serous adenocarcinoma. Results The positive expression rate of nm23 protein in 66 cases of ovarian serous adenocarcinoma was 65.2%, while the positive rates of nm23 in 89 cases of Ⅰ, Ⅱ and Ⅲ tumors were 65.5%, 66.7% and 43.5% respectively. The positive rate of nm23 protein decreased with the increase of pathological grade. There was significant difference between grade Ⅰ and grade Ⅲ, grade Ⅰ and grade Ⅱ and grade Ⅲ (P <0.05), and was correlated with tumor size, metastasis and prognosis P <0 0 1, P <0 0 5). Conclusion The detection of nm23 protein can be helpful in judging the malignant degree and prognosis of ovarian serous adenocarcinoma