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用随机对照方法静脉滴注苯妥英治疗急性脑梗塞２５例，观察神经功能缺失改变及首剂苯妥英静滴前后的脑循环动力学改变，结果显示，用苯妥英治疗后，脑梗塞患者神经功能缺失明显改善，总有效率达９２％，显效率达６８％，与未用苯妥英组比较差异显著（Ｐ＜０．０５）；治疗期间未见明显毒副作用。静滴苯妥英２５０ｍｇ后，颈动脉系统血流速度及血流量增加，外周小血管阻力下降，但无统计学差异。而静滴苯妥英５００ｍｇ，则可显著增加颈动脉系统血流速度及血流量（ｐ＜０．０１），降低外周小血管阻力（Ｐ＜０．０１）。提示苯妥英对缺血性脑组织有一定保护作用。
A randomized controlled trial of intravenous infusion of phenytoin in patients with acute cerebral infarction in 25 cases, changes in neurological deficit and the first dose of phenytoin before and after intravenous infusion of cerebral circulatory dynamics changes showed that with phenytoin treatment, neurological deficits significantly improved in patients with cerebral infarction , With a total effective rate of 92% and a markedly effective rate of 68%, which was significantly different from that of the phenytoin group (P <0.05). No obvious side effects were observed during the treatment. After intravenous infusion of phenytoin 250mg, the carotid system blood flow velocity and blood flow increased, peripheral small vessel resistance decreased, but no significant difference. The intravenous infusion of phenytoin 500mg, can significantly increase the carotid system blood flow velocity and blood flow (p <0.01), reduce peripheral vascular resistance (P <0.01). Tip phenytoin on ischemic brain tissue has a protective effect.