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目的:评估血管内栓塞治疗和显微手术夹闭两种治疗方法对颅内动脉瘤患者认知功能的影响。方法:选取2014年3月至2015年9月重庆市中医院神经外科收治的颅内动脉瘤患者80例,按随机数字表法分为对照组和实验组各40例,对照组采用显微手术夹闭治疗,实验组采用血管内栓塞治疗。应用简易精神状态检查量表(MMSE)评估术后认知功能,并对比两组住院时间、院内死亡率和1年死亡率以及术后不良反应发生率。结果:实验组MMSE总分为(26.78±0.85)分,高于对照组的(22.25±0.63)分(P<0.05);实验组认知功能障碍率为37.50%,低于对照组的55.00%(P<0.05);实验组住院时间为(6.7±3.9)天,低于对照组的(9.6±4.5)天(P<0.05),两组院内死亡率和1年死亡率比较无统计学差异(P>0.05);两组术后不良反应发生率比较无统计学差异(P>0.05)。结论:血管内介入治疗可改善颅内动脉瘤患者治疗后的认知功能,缩短住院时间。
OBJECTIVE: To assess the effect of intravascular embolization and microsurgical clipping on cognitive function in patients with intracranial aneurysms. Methods: From March 2014 to September 2015, 80 patients with intracranial aneurysm admitted to Department of Neurosurgery, Chongqing Hospital of Traditional Chinese Medicine were divided into control group and experimental group according to random number table method, 40 cases in each group. The control group was treated by microsurgery Closure treatment, the experimental group by endovascular embolization. MMSE was used to evaluate the postoperative cognitive function. The hospitalization time, in-hospital mortality, 1-year mortality and postoperative adverse reactions were compared between the two groups. Results: The score of MMSE in the experimental group was (26.78 ± 0.85) points higher than that in the control group (22.25 ± 0.63) (P <0.05). The cognitive impairment rate in the experimental group was 37.50%, which was lower than 55.00% (P <0.05). The hospitalization time in the experimental group was (6.7 ± 3.9) days, which was lower than that in the control group (9.6 ± 4.5) days (P <0.05). There was no significant difference in in-hospital mortality and 1-year mortality (P> 0.05). There was no significant difference in the incidence of postoperative adverse reactions between the two groups (P> 0.05). Conclusion: Endovascular intervention can improve the cognitive function of patients with intracranial aneurysms after treatment and shorten the hospital stay.