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目的比较甘油果糖与甘露醇治疗急性脑梗塞（ＡＣＩ）及抗脑水肿疗效和副作用。方法将１７８例ＡＣＩ患者随机分组，在同样治疗基础上一组加用１０％甘油果糖２５０ｍｌ，重度１次／６～８ｈ，轻中度１次／１２ｈ，静滴；另一组用２０％甘露醇２５０ｍｌ，重度１次／６～８ｈ，轻中度１次／１２ｈ，静注。结果两组间治疗ＡＣＩ及抗水肿疗效显著（Ｐ＜０．０５），两组之间疗效比较无显著差异（Ｐ＞０．０５），甘油组肾功能损害明显低于甘露醇组（Ｐ＜０．０１）。结论甘油为治疗ＡＣＩ有效、安全、方便的理想药物，除极需迅速降低颅内压外建议选用。
Objective To compare the efficacy and side effects of glycerol fructose and mannitol in the treatment of acute cerebral infarction (ACI) and cerebral edema. Methods A total of 178 patients with ACI were randomly divided into two groups. On the basis of the same treatment, one group was treated with 250ml of 10% glycerol fructose, once a day for 6 to 8 hours, once a day for 12 hours, Alcohol 250ml, severe 1/6 ~ 8h, mild to moderate 1 / 12h, intravenous injection. Results There was a significant difference (P <0.05) between the two groups in the treatment of ACI and anti-edema (P <0.05). There was no significant difference between the two groups (P> 0.05). The renal damage in glycerol group was significantly lower than that in the mannitol group (P < 0.01). Conclusion Glycerol is an effective, safe and convenient drug for the treatment of ACI. It is recommended to use glycerin in addition to the need to rapidly reduce intracranial pressure.