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激素治疗特发性肾病综合症可见临床缓解,但1/3病人经常复发仍是一个主要的问题。病人第1次缓解后,是否复发还无法预知。但3个月内首次复发者,往往伴有以后的经常复发。撤激素后病人有暂时性的肾上腺皮质功能减退。类风湿性关节炎病人在撤激素后常常伴有症状的复发。为此,作者研究特发性肾病综合征首次发作时,强的松治疗对肾上腺皮质的活性的作用及其活性与临床症状和病程的联系。病人和方法:作者观察了23名病儿,年龄为1.6～14.7岁,均为首次发作对激素敏感的特发性肾病综合征。肾病综合征、缓解、复发和“经常复发者”的定义和治疗方案均与国际小儿肾脏病研究中心所定标准一致。
Hormonal treatment of idiopathic nephrotic syndrome can be seen in clinical remission, but recurrence of 1/3 of patients is still a major problem. After the patient is relieved for the first time, it is impossible to predict whether the patient will relapse. But the first relapse within 3 months, often with subsequent recurrences. After withdrawal of hormone patients have temporary adrenal insufficiency. Patients with rheumatoid arthritis often have symptomatic relapse after withdrawal of hormone. To this end, the authors study the effect of prednisone on adrenal cortical activity and its association with clinical symptoms and duration at the first episode of idiopathic nephrotic syndrome. PATIENTS AND METHODS: The authors looked at 23 sick children aged from 1.6 to 14.7 years old, both of whom were first-episode hormone-sensitive idiopathic nephrotic syndromes. Nephrotic syndrome, remission, relapse and the definition of “recurrence” and treatment programs are in line with the International Children’s Nephrology Center set standards.