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本文比较了用油包水(W/O)乳化法和直接压制法制得的聚二聚脂肪酸(FA)及聚癸二酸门则共聚物(聚酥)颗粒的药物溶出特性和聚合物降解特性,所选的模型药物为酸性橙(AO)和对硝基苯胺(P-NA)。聚酸小圆片及颗粒的制备(1)W/O乳化法:含模型药的100瓜水溶液倒入含235mg?
In this paper, the drug dissolution properties and polymer degradation characteristics of poly (dimerized fatty acid) (FA) and poly (sebacic acid) and poly (sebacic acid) copolymer particles prepared by W / O emulsification and direct compression were compared. The selected model drugs were Acid Orange (AO) and p-Nitroaniline (P-NA). Poly acid small pellets and granules Preparation (1) W / O Emulsification: Model drug containing 100 melons poured into the solution containing 235mg?