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目的为进一步了解老年人急性白血病的分子生物学特征。方法应用聚合酶链反应（PCR）检测28例老年人急性白血病免疫球蛋白重链（IgH）则基因重排结果66.7％（4／6）老年人急性淋巴细胞白血病（ALL）和40．9％（9／22）急性非淋巴细胞白血病（ANLL）存在IgH基因重排：IgH基因重排阳性老年人ANLL治疗缓解率（22．2％）显著低于IgH基因重排阴性老年人ANLL（66.7％）（P＜0.05）。结论应用PCR技术检测老年人急性白血病基因重排可帮助了解老年人白血病的分子生物学特征和预后，此方面尚需进一步研究。
The purpose is to further understand the molecular biology characteristics of elderly patients with acute leukemia. METHODS: Polymerase chain reaction (PCR) was used to detect the genetic rearrangement of immunoglobulin heavy chain (IgH) genes in 28 elderly patients with acute leukemia. 66.7% (4/6) elderly patients with acute lymphoblastic leukemia (ALL) and 40.9% (9/22) IgH gene rearrangement in acute nonlymphocytic leukemia (ANLL): The response rate of ANLL treatment in elderly patients with IgH gene rearrangement was significantly lower (22.2%) than that of ILLH gene rearrangement negative elderly (66.7%) () (P<0.05). Conclusion The application of polymerase chain reaction (PCR) to detect the gene rearrangement of elderly patients with acute leukemia can help to understand the molecular biology characteristics and prognosis of elderly patients with leukemia. Further research is needed in this regard.