大多数酯类药物给药后受到结合在小肠粘膜的酯酶的水解,而水解的程度可影响到药物的药理作用和毒性。本文研究小肠酯酶在药物吸收时对酯类药物的水解能力,并比较了人、大鼠、小鼠、豚鼠、兔和狗等的小肠酯酶的特性。在外翻小肠实验中茚满基羧 Most ester drugs are hydrolyzed by esterases that bind to the intestinal mucosa after administration, and the extent of hydrolysis can affect the pharmacological effects and toxicity of the drug. In this paper, the intestinal esterase hydrolysis of drugs on the ability of ester hydrolysis, and compared human, rat, mouse, guinea pig, rabbit and dog esterases and other characteristics of the small intestine. Indole carboxylate in the valgus small intestine experiment