大量临床和实验室研究证明,血和尿中红细胞生成素水平与组织氧合程度呈反相关。作者用敏感而特异的放射免疫测定法检测红细胞生成素,发现镰状细胞性贫血和年龄直接影响血红蛋白浓度与红细胞生成素之间的关系。作者研究了28例镰状细胞性贫血病人,其中成人患者10例,儿童和青年18例。18例儿童和青年患者中,男性12例,女性6例,平均年龄是9.2±5.5岁, A large number of clinical and laboratory studies have shown that erythropoietin levels in blood and urine are inversely correlated with the degree of tissue oxygenation. The authors used a sensitive and specific radioimmunoassay detection of erythropoietin and found that sickle cell anemia and age directly affect the relationship between hemoglobin concentration and erythropoietin. The authors studied 28 patients with sickle cell anemia, including 10 adult patients, 18 children and youth. Of the 18 children and young patients, 12 were males and 6 were females with an average age of 9.2 ± 5.5 years,