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目的:探讨细菌性阴道病孕妇宫颈阴道分泌物中MMP-8、MMP-9和FFN的水平及在临床早产诊断中的价值。方法:选取细菌性阴道病孕妇40例作为研究对象,并选取同期同孕龄的正常孕妇40例作为对照组。分析对照组和观察组孕妇宫颈阴道分泌物中MMP-8、MMP-9和FFN的水平,并分析MMP-8、MMP-9和FFN对临床早产诊断的准确性、灵敏性和特异性。结果:与对照组比较,观察组孕妇宫颈阴道分泌物中MMP-8、MMP-9和FFN的水平明显升高(P<0.05)。早产孕妇宫颈阴道分泌物中MMP-8、MMP-9和FFN的水平较足月分娩的孕妇明显增加(P<0.05)。Hosmer-Lemeshow拟合优度检验显示,MMP-8、MMP-9和FFN的水平对细菌性阴道病妊娠结局的预测具有较好的校准度。当MMP-8、MMP-9和FFN水平为143.55 pg/ml,214.89 pg/ml和311.67 ng/ml时,其在细菌性阴道病孕妇妊娠结局的临床诊断中具有较高的准确性、灵敏性和特异性。结论:MMP-8、MMP-9和FFN在细菌性阴道病孕妇宫颈阴道分泌物中水平明显增加,可以作为临床细菌性阴道病妊娠结局的诊断标志。
Objective: To investigate the levels of MMP-8, MMP-9 and FFN in cervicovaginal secretions of bacterial vaginosis and its value in the diagnosis of preterm labor. Methods: Forty cases of bacterial vaginosis were selected as the research object, and 40 normal pregnant women of the same gestational age were selected as the control group. The levels of MMP-8, MMP-9 and FFN in cervical vaginal secretions of control group and observation group were analyzed. The accuracy, sensitivity and specificity of MMP-8, MMP-9 and FFN for the diagnosis of clinical preterm labor were analyzed. Results: Compared with the control group, the levels of MMP-8, MMP-9 and FFN in cervix vaginal secretions of the observation group were significantly increased (P <0.05). The levels of MMP-8, MMP-9 and FFN in cervical vaginal secretions of premature pregnant women were significantly higher than those of full-term pregnant women (P <0.05). The Hosmer-Lemeshow goodness-of-fit test showed that the levels of MMP-8, MMP-9 and FFN had a good calibration for predicting the pregnancy outcome of bacterial vaginosis. When the levels of MMP-8, MMP-9 and FFN were 143.55 pg / ml, 214.89 pg / ml and 311.67 ng / ml, they were more accurate and sensitive in clinical diagnosis of bacterial vaginosis in pregnant women And specificity. Conclusion: The levels of MMP-8, MMP-9 and FFN in cervicovaginal secretions of bacterial vaginosis are significantly increased, which can be used as a diagnostic marker of clinical pregnancy outcome of bacterial vaginosis.