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目的:观察脑梗死患者血浆S-100蛋白的浓度变化,以评价其与脑梗死诊断及预后的关系。方法:应用ELISA法对35例急性脑梗死患者血浆S-100蛋白水平进行动态检测,同时应用NIHSS进行神经功能缺损评分及CT扫描,并与30例对照组病人进行比较。结果:病例组病人S-100浓度明显升高,2～3天达到峰值,且严重神经功能缺失的病人,S-100升高更明显,S-100>1.0μg/L或NIHSS>12分提示患者预后不良。结论:缺血性脑梗死后血浆中S-100蛋白的出现与坏死的神经胶质细胞漏出有关,并通过受损的血脑屏障进入血液,S-100蛋白可作为缺血性脑损伤尤其是大面积脑梗死早期的外周标志物,是比CT更为敏感的指标,对指导治疗有帮助。
Objective: To observe the plasma concentration of S-100 protein in patients with cerebral infarction to evaluate its relationship with the diagnosis and prognosis of cerebral infarction. Methods: Thirty-five patients with acute cerebral infarction were enrolled in this study. The plasma levels of S-100 protein were detected by ELISA. Neurological deficit scores and CT scans were performed with NIHSS and compared with 30 control subjects. Results: The S-100 concentration was significantly increased in patients in the case group, peaked at 2 to 3 days, and the severity of neurological deficit in patients with S-100 increased more significantly, S-100> 1.0μg / L or NIHSS> 12 tips Patients with poor prognosis. CONCLUSIONS: The presence of S-100 protein in plasma following ischemic cerebral infarction is associated with leakage of necrotic glial cells and entry into the bloodstream through the impaired blood-brain barrier. S-100 protein may serve as a marker for ischemic brain injury, especially Early peripheral cerebral infarction large area markers, is more sensitive than CT indicators, to guide the treatment of help.