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目的:评估经尿道等离子电切联合吡柔比星膀胱灌注治疗腺性膀胱炎的治疗效果。方法:对经膀胱镜及病理学检查确诊的238例腺性膀胱炎患者行经尿道等离子电切术,术后随机分为两组,一组118例术后即刻膀胱灌注单剂吡柔比星(灌注组),一组120例术后不灌注,常规随访观察(对照组)。结果:术后平均随访24(12～52)个月,灌注组有82例治愈,无病理学复发,症状缓解,术后半年复查膀胱镜见膀胱黏膜逐渐恢复为移行上皮覆盖;12例治疗后6～21个月病理学复发,1例3年内反复发作4次,行膀胱部分切除后治愈,无一例发生恶变;24例术后尿频、下腹痛症状仍然存在。对照组有61例治愈,无病理学复发,症状缓解;21例治疗后6～21个月病理学复发,经再次电切和吡柔比星膀胱灌注后治愈;38例术后尿频、下腹痛症状仍然存在。结论:经尿道等离子电切是治疗腺性膀胱炎的有效方法,术后给予单剂吡柔比星即刻膀胱灌注化疗可提高治愈率。
Objective: To evaluate the therapeutic effect of transurethral resection combined with pirarubicin on bladder cystitis. Methods: A total of 238 patients with cystitis glandula were diagnosed by cystoscopy and pathology. All patients were randomly divided into two groups. One group of 118 patients received intravesical instillation of a single dose of pirarubicin Perfusion group), a group of 120 patients were not perfusion, routine follow-up observation (control group). Results: After an average follow-up of 24 (12-52) months, 82 cases were cured in the perfusion group, no pathological recurrence was found and the symptoms were relieved. Bladder mucosa gradually recovered to transitional epithelium after cystoscopy for 6 months. 6-21 months pathological recurrence, 1 case of repeated attacks within 3 years 4 times, partial bladder resection cured, no case of malignant transformation; 24 cases of postoperative urinary frequency, abdominal pain symptoms still exist. In the control group, 61 cases were cured, no pathological recurrence was found, and the symptoms were relieved. 21 cases recovered pathologically 6 to 21 months after treatment, and were cured after reperfusion and pirarubicin instillation. 38 cases had frequent urination, Symptoms still exist. Conclusion: Transurethral resection of the plasma is an effective method for the treatment of cystitis glandularis. Immediate intravesical instillation chemotherapy with a single dose of pirarubicin increases the cure rate.