栓剂的溶出试验对评价栓剂质量及药物的体内溶出特性很重要。对一般栓剂的溶出试验已有报道,但对缓释栓剂尚未见报道。为此以脂溶性基质Witepsol H15制备含富马酸(F10、40或80mg)或己二酸(A10、40或80mg)的双氯灭痛钠(DCNa)缓释栓剂(每粒含DCNa 25mg)。用村西法、田部等法、圆筒滤纸法和转篮法等四种溶出试验方法,进行DCNa缓释栓剂的溶出试验,结果均 Suppository dissolution test evaluation of suppository quality and drug dissolution characteristics in vivo is very important. Dissolution tests have been reported for general suppositories, but no sustained release suppositories have been reported. For this purpose, a dacrine (DCNa) sustained-release suppository (containing 25 mg DCNa per capsule) containing fumaric acid (F10, 40 or 80 mg) or adipic acid (A10, 40 or 80 mg) was prepared with fat-soluble matrix Witepsol H15. The dissolution test of DCNa sustained-release suppository was carried out by four dissolution test methods such as Village West Method, Field Method, cylinder filter paper method and spin-basket method, and the results were